Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP).
SJ Braunhut, MA Moses - Journal of Biological Chemistry, 1994 - ASBMB
We have previously reported that vitamin A inhibits the growth of capillary endothelial cells
(EC)(Braunhut, SJ, and Palomares, M.(1991) Microvasc. Res. 41, 47-62). In this study, we
have analyzed the effect of retinoids on the production and activity of enzymes involved in
the proteolytic degradation of extracellular matrix (ECM) by EC. Substrate gel
electrophoresis (zymography) revealed several major matrix metalloproteinases (MMP), of
approximately 98-96, 72-68, and 46-45 kDa, whose activities were altered in their amounts …
(EC)(Braunhut, SJ, and Palomares, M.(1991) Microvasc. Res. 41, 47-62). In this study, we
have analyzed the effect of retinoids on the production and activity of enzymes involved in
the proteolytic degradation of extracellular matrix (ECM) by EC. Substrate gel
electrophoresis (zymography) revealed several major matrix metalloproteinases (MMP), of
approximately 98-96, 72-68, and 46-45 kDa, whose activities were altered in their amounts …
