[HTML][HTML] Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-α
CT Taylor, N Fueki, A Agah, RM Hershberg… - Journal of Biological …, 1999 - ASBMB
Tissue hypoxia is intimately associated with a number of chronic inflammatory conditions of
the intestine. In this study, we investigated the impact of hypoxia on the expression of a
panel of inflammatory mediators by intestinal epithelia. Initial experiments revealed that
epithelial (T84 cell) exposure to ambient hypoxia evoked a time-dependent induction of the
proinflammatory markers tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and major
histocompatibility complex (MHC) class II (37±6.1-, 7±0.8-, and 9±0.9-fold increase over …
the intestine. In this study, we investigated the impact of hypoxia on the expression of a
panel of inflammatory mediators by intestinal epithelia. Initial experiments revealed that
epithelial (T84 cell) exposure to ambient hypoxia evoked a time-dependent induction of the
proinflammatory markers tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and major
histocompatibility complex (MHC) class II (37±6.1-, 7±0.8-, and 9±0.9-fold increase over …