Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas
N Théret, O Musso, B Turlin, D Lotrian… - Hepatology, 2001 - journals.lww.com
Abstract Matrix metalloproteinase–2 (MMP2) is a key enzyme in the process of extracellular
matrix remodeling involved in tumor invasion and metastasis. The activation of MMP2
involves interplay with the membrane type–matrix metalloproteinase–1 (MT1–MMP) and the
tissue inhibitor of metalloproteinase–2 (TIMP2). In vitro, activated hepatic stellate cells are a
main source of MMP2 and collagen I induces MMP2 activation. The steady–state mRNA
levels of MMP2, MT1–MMP, TIMP2, collagen I, collagen IV, and laminin γ1 were compared …
matrix remodeling involved in tumor invasion and metastasis. The activation of MMP2
involves interplay with the membrane type–matrix metalloproteinase–1 (MT1–MMP) and the
tissue inhibitor of metalloproteinase–2 (TIMP2). In vitro, activated hepatic stellate cells are a
main source of MMP2 and collagen I induces MMP2 activation. The steady–state mRNA
levels of MMP2, MT1–MMP, TIMP2, collagen I, collagen IV, and laminin γ1 were compared …
