[HTML][HTML] Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44
M Dohadwala, J Luo, L Zhu, Y Lin, GJ Dougherty… - Journal of Biological …, 2001 - ASBMB
Elevated tumor cyclooxygenase (COX-2) expression is associated with increased
angiogenesis, tumor invasion, and suppression of host immunity. We have previously shown
that genetic inhibition of tumor COX-2 expression reverses the immunosuppression induced
by non-small cell lung cancer (NSCLC). To assess the impact of COX-2 expression in lung
cancer invasiveness, NSCLC cell lines were transduced with a retroviral vector expressing
the human COX-2 cDNA in the sense (COX-2-S) and antisense (COX-2-AS) orientations …
angiogenesis, tumor invasion, and suppression of host immunity. We have previously shown
that genetic inhibition of tumor COX-2 expression reverses the immunosuppression induced
by non-small cell lung cancer (NSCLC). To assess the impact of COX-2 expression in lung
cancer invasiveness, NSCLC cell lines were transduced with a retroviral vector expressing
the human COX-2 cDNA in the sense (COX-2-S) and antisense (COX-2-AS) orientations …