Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas
Q Su, CH Schröder, WJ Hofmann, G Otto… - Hepatology, 1998 - journals.lww.com
Transactivation of cellular genes and functional inactivation of p53 by the hepatitis B virus
(HBV) X gene-encoded protein (HBx) are proposed as alternative mechanisms for induction
of hepatocellular carcinomas (HCCs) in chronic HBV infection. Using an
immunohistochemical approach, we studied the expression of HBx in 39 explanted livers
with HBV-associated disease. Because the data reported previously have been inconsistent,
possibly due to the application of different antibodies, we compared results with 5 polyclonal …
(HBV) X gene-encoded protein (HBx) are proposed as alternative mechanisms for induction
of hepatocellular carcinomas (HCCs) in chronic HBV infection. Using an
immunohistochemical approach, we studied the expression of HBx in 39 explanted livers
with HBV-associated disease. Because the data reported previously have been inconsistent,
possibly due to the application of different antibodies, we compared results with 5 polyclonal …