[HTML][HTML] The herbicide paraquat causes up-regulation and aggregation of α-synuclein in mice: paraquat and α-synuclein
AB Manning-Bog, AL McCormack, J Li… - Journal of Biological …, 2002 - ASBMB
α-Synuclein-containing aggregates represent a feature of a variety of neurodegenerative
disorders, including Parkinson's disease (PD). However, mechanisms that promote
intraneuronal α-synuclein assembly remain poorly understood. Because pesticides,
particularly the herbicide paraquat, have been suggested to play a role as PD risk factors,
the hypothesis that interactions between α-synuclein and these environmental agents may
contribute to aggregate formation was tested in this study. Paraquat markedly accelerated …
disorders, including Parkinson's disease (PD). However, mechanisms that promote
intraneuronal α-synuclein assembly remain poorly understood. Because pesticides,
particularly the herbicide paraquat, have been suggested to play a role as PD risk factors,
the hypothesis that interactions between α-synuclein and these environmental agents may
contribute to aggregate formation was tested in this study. Paraquat markedly accelerated …