β-Endorphin-containing memory-cells and μ-opioid receptors undergo transport to peripheral inflamed tissue
Immunocyte-derived β-endorphin can activate peripheral opioid receptors on sensory
neurons to inhibit pain within inflamed tissue. This study examined μ-opioid receptors (MOR)
on sensory nerves and β-endorphin (END) in activated/memory CD4+ cells (the
predominant population homing to inflamed tissue). We found an upregulation of MOR in
dorsal root ganglia, an increased axonal transport of MOR in the sciatic nerve and an
accumulation of MOR in peripheral nerve terminals in Freund's adjuvant-induced hindpaw …
neurons to inhibit pain within inflamed tissue. This study examined μ-opioid receptors (MOR)
on sensory nerves and β-endorphin (END) in activated/memory CD4+ cells (the
predominant population homing to inflamed tissue). We found an upregulation of MOR in
dorsal root ganglia, an increased axonal transport of MOR in the sciatic nerve and an
accumulation of MOR in peripheral nerve terminals in Freund's adjuvant-induced hindpaw …