Molecular diversity of pacemaker ion channels
UB Kaupp, R Seifert - Annual review of physiology, 2001 - annualreviews.org
UB Kaupp, R Seifert
Annual review of physiology, 2001•annualreviews.org▪ Abstract Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides
were first discovered more than 20 years ago. Recently the molecular identity of the
underlying channels has been unveiled. The structural features of the protein sequences are
discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and
ion permeation. Coverage includes a comparison of the biophysical properties of
recombinant and native channels and their significance for the physiological functions of …
were first discovered more than 20 years ago. Recently the molecular identity of the
underlying channels has been unveiled. The structural features of the protein sequences are
discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and
ion permeation. Coverage includes a comparison of the biophysical properties of
recombinant and native channels and their significance for the physiological functions of …
▪ Abstract
Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the biophysical properties of recombinant and native channels and their significance for the physiological functions of these channels.
Annual Reviews