H yperpolarization-activated, c yclic n ucleotide-gated (HCN) channels, underlying
'pacemaker'currents (If/Ih), are involved in pacemaker activity of cardiac sinoatrial node
myocytes and central neurons. Several cDNAs deriving from four different genes were
recently identified which code for channels characterized by six transmembrane domains
and a cyclic nucleotide binding domain. We report here the identification of the human
HCN2 gene and show that its functional expression in a human kidney cell line generates a …