Vascular endothelial growth factor upregulation in transient global ischemia induced by cardiac arrest and resuscitation in rat brain
P Pichiule, JC Chávez, K Xu, JC LaManna - Molecular brain research, 1999 - Elsevier
This study examined vascular endothelial growth factor (VEGF) expression in rat brain after
reversible global cerebral ischemia produced by cardiac arrest and resuscitation. Three
alternative splicing forms, VEGF188, VEGF164 and VEGF120, were observed in cortex,
hippocampus and brainstem by RT–PCR analysis. After 24 h of recovery from cardiac arrest,
mRNA levels corresponding to VEGF188 and VEGF164 were significantly increased by
about double in all the regions analyzed. These mRNA levels remained elevated at 24 and …
reversible global cerebral ischemia produced by cardiac arrest and resuscitation. Three
alternative splicing forms, VEGF188, VEGF164 and VEGF120, were observed in cortex,
hippocampus and brainstem by RT–PCR analysis. After 24 h of recovery from cardiac arrest,
mRNA levels corresponding to VEGF188 and VEGF164 were significantly increased by
about double in all the regions analyzed. These mRNA levels remained elevated at 24 and …