Generation and maintenance of memory T cells

J Sprent, CD Surh - Current opinion in immunology, 2001 - Elsevier
J Sprent, CD Surh
Current opinion in immunology, 2001Elsevier
Typical immune responses lead to the prominent clonal expansion of antigen-specific T cells
followed by their differentiation into effector cells. Most effector cells die at the end of the
immune response but some of the responding cells survive and form long-lived memory
cells. The factors controlling the formation and survival of memory T cells are discussed.
Recent evidence suggests that T memory cells arise from a subset of effector cells. The
longevity of T memory cells may require continuous contact with cytokines, notably IL-15 for …
Typical immune responses lead to the prominent clonal expansion of antigen-specific T cells followed by their differentiation into effector cells. Most effector cells die at the end of the immune response but some of the responding cells survive and form long-lived memory cells. The factors controlling the formation and survival of memory T cells are discussed. Recent evidence suggests that T memory cells arise from a subset of effector cells. The longevity of T memory cells may require continuous contact with cytokines, notably IL-15 for CD8+ cells.
Elsevier