[HTML][HTML] Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin
H Ihara, DT Denhardt, K Furuya, T Yamashita… - Journal of Biological …, 2001 - ASBMB
Osteopontin is an RGDS-containing protein that acts as a ligand for the α v β 3 integrin,
which is abundantly expressed in osteoclasts, cells responsible for bone resorption in
osteopenic diseases such as osteoporosis and hyperparathyroidism. However, the role of
osteopontin in the process of bone resorption has not yet been fully understood. Therefore,
we investigated the direct function of osteopontin in bone resorption using an organ culture
system. The amount of 45 Ca released from the osteopontin-deficient bones was not …
which is abundantly expressed in osteoclasts, cells responsible for bone resorption in
osteopenic diseases such as osteoporosis and hyperparathyroidism. However, the role of
osteopontin in the process of bone resorption has not yet been fully understood. Therefore,
we investigated the direct function of osteopontin in bone resorption using an organ culture
system. The amount of 45 Ca released from the osteopontin-deficient bones was not …