BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

JS Thompson, SA Bixler, F Qian, K Vora, ML Scott… - Science, 2001 - science.org
JS Thompson, SA Bixler, F Qian, K Vora, ML Scott, TG Cachero, C Hession, P Schneider
Science, 2001science.org
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor
from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two
receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed
BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role
for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in
A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF …
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.
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