Activation of rat basophilic leukemia cells by ϵBP, an IgE-binding endogenous lectin
RI Zuberi, LG Frigeri, FT Liu - Cellular immunology, 1994 - Elsevier
IgE-binding protein (ϵBP) is a β-galactoside-binding animal lectin identified by its affinity for
IgE. We have reported that ϵBP also binds the mast cell high-affinity IgE receptor (FcϵRI),
via lectin-carbohydrate interaction. We have now studied the physiological significance of
ϵBP-IgE-FcϵRI interactions in mast cell activation using rat basophilic leukemia (RBL) cells
as the model system. We report here that both unsensitized and IgE-sensitized RBL cells are
activated upon exposure to ϵBP-coated surfaces. Activation of RBL cells by the lectin ϵBP …
IgE. We have reported that ϵBP also binds the mast cell high-affinity IgE receptor (FcϵRI),
via lectin-carbohydrate interaction. We have now studied the physiological significance of
ϵBP-IgE-FcϵRI interactions in mast cell activation using rat basophilic leukemia (RBL) cells
as the model system. We report here that both unsensitized and IgE-sensitized RBL cells are
activated upon exposure to ϵBP-coated surfaces. Activation of RBL cells by the lectin ϵBP …