Cloning of the murine platelet glycoprotein Ibα gene highlighting species-specific platelet adhesion
J Ware, S Russell, ZM Ruggeri - Blood Cells, Molecules, and Diseases, 1997 - Elsevier
We report the sequence of a 2,779 base pair genomic DNA fragment containing the mouse
glycoprotein (GP) Ibα gene. Similar to its human counterpart, the mouse GP Ibα gene
contains a single exon encoding a 734-residue GP Ibα precursor polypeptide. Comparative
analysis between human and mouse polypeptides reveals a 75% sequence similarity
between the amino-terminal domain of each polypeptide. However, there is sequence
divergence within a short linear sequence of the amino-terminal domain previously …
glycoprotein (GP) Ibα gene. Similar to its human counterpart, the mouse GP Ibα gene
contains a single exon encoding a 734-residue GP Ibα precursor polypeptide. Comparative
analysis between human and mouse polypeptides reveals a 75% sequence similarity
between the amino-terminal domain of each polypeptide. However, there is sequence
divergence within a short linear sequence of the amino-terminal domain previously …
