Structure, sequence and expression of the hepatitis delta (δ) viral genome
KS Wang, QL Choo, AJ Weiner, JH Ou, RC Najarian… - Nature, 1986 - nature.com
KS Wang, QL Choo, AJ Weiner, JH Ou, RC Najarian, RM Thayer, GT Mullenbach…
Nature, 1986•nature.comBiochemical and electron microscopic data indicate that the human hepatitis δ viral agent
contains a covalently closed circular and single-stranded RNA genome that has certain
similarities with viroid-like agents from plants. The sequence of the viral genome (1,678
nucleotides) has been determined and an open reading frame within the complementary
strand has been shown to encode an antigen that binds specifically to antisera from patients
with chronic hepatitis δ viral infections.
contains a covalently closed circular and single-stranded RNA genome that has certain
similarities with viroid-like agents from plants. The sequence of the viral genome (1,678
nucleotides) has been determined and an open reading frame within the complementary
strand has been shown to encode an antigen that binds specifically to antisera from patients
with chronic hepatitis δ viral infections.
Abstract
Biochemical and electron microscopic data indicate that the human hepatitis δ viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis δ viral infections.
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