[HTML][HTML] Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of …
Y Ohmori, RD Schreiber, TA Hamilton - Journal of Biological Chemistry, 1997 - ASBMB
Interferon-γ (IFNγ) and tumor necrosis factor-α (TNFα) cooperate to induce the expression of
many gene products during inflammation. The present report demonstrates that a portion of
this cooperativity is mediated by synergism between two distinct transcription factors: signal
transducer and activator of transcription 1 (STAT1) and nuclear factor κB (NF-κB). IFNγ and
TNFα synergistically induce expression of mRNAs encoding interferon regulatory factor-1
(IRF-1), intercellular adhesion molecule-1, Mig (monokine induced by γ-interferon), and …
many gene products during inflammation. The present report demonstrates that a portion of
this cooperativity is mediated by synergism between two distinct transcription factors: signal
transducer and activator of transcription 1 (STAT1) and nuclear factor κB (NF-κB). IFNγ and
TNFα synergistically induce expression of mRNAs encoding interferon regulatory factor-1
(IRF-1), intercellular adhesion molecule-1, Mig (monokine induced by γ-interferon), and …