COX-2 and the cyclopentenone prostaglandins-a new chapter in the book of inflammation?
PR Colville–Nash, DW Gilroy - Prostaglandins & other Lipid Mediators, 2000 - Elsevier
Since the discovery by Vane in 1971 [1] that the nonsteroidal anti-inflammatory drugs
(NSAIDs) shared a common function of inhibiting cyclooxygenase (COX) and thus
prostaglandin (PG) synthesis, there has been intense interest in the role of this enzyme
pathway and it's products in both physiology and pathophysiology. With the development of
new techniques and therapeutic agents over recent years, a number of seemingly disparate
lines of research are now converging to provide new insights into the inflammatory …
(NSAIDs) shared a common function of inhibiting cyclooxygenase (COX) and thus
prostaglandin (PG) synthesis, there has been intense interest in the role of this enzyme
pathway and it's products in both physiology and pathophysiology. With the development of
new techniques and therapeutic agents over recent years, a number of seemingly disparate
lines of research are now converging to provide new insights into the inflammatory …