Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis
LJ Roberts II, BJ Sweetman - Prostaglandins, 1985 - Elsevier
Increased production of prostaglandin D 2 was recently demonstrated in patients with
systemic mastocytosis. One female patient investigated with mastocytosis was found to have
overproduction of prostaglandin D 2 of such magnitude (150-fold above normal) that it
provided the unique opportunity to delineate the metabolic fate of endogenously
synthesized prostaglandin D 2. A five percent aliquot of a twenty-four hour urine collection
from the patient was extracted, purified by silicic acid chromatography, methylated, and …
systemic mastocytosis. One female patient investigated with mastocytosis was found to have
overproduction of prostaglandin D 2 of such magnitude (150-fold above normal) that it
provided the unique opportunity to delineate the metabolic fate of endogenously
synthesized prostaglandin D 2. A five percent aliquot of a twenty-four hour urine collection
from the patient was extracted, purified by silicic acid chromatography, methylated, and …
