Guanylyl cyclase-C receptor mRNA distribution along the rat nephron
SL Carrithers, B Taylor, WY Cai, BR Johnson, CE Ott… - Regulatory peptides, 2000 - Elsevier
Guanylin (GN) and uroguanylin (UGN) are two recently identified peptides that have been
shown to affect water and electrolyte transport in both the intestine and the kidney.
Mechanistically, the effects of both peptides are thought to be mediated by intracellular
cGMP which results from ligand binding to a plasma membrane guanylyl cyclase-C (GC-C)
receptor. To date, the specific intrarenal site (s) of GN and UGN action have not been
established. To begin to address this issue, the present studies utilized semi-quantitative RT …
shown to affect water and electrolyte transport in both the intestine and the kidney.
Mechanistically, the effects of both peptides are thought to be mediated by intracellular
cGMP which results from ligand binding to a plasma membrane guanylyl cyclase-C (GC-C)
receptor. To date, the specific intrarenal site (s) of GN and UGN action have not been
established. To begin to address this issue, the present studies utilized semi-quantitative RT …