[HTML][HTML] Loss of lymphotoxin-α but not tumor necrosis factor-α reduces atherosclerosis in mice
SA Schreyer, CM Vick, RC LeBoeuf - Journal of Biological Chemistry, 2002 - ASBMB
Inflammatory processes are involved with all phases of atherosclerotic lesion growth. Tumor
necrosis factor-α (TNFα) is an inflammatory cytokine that is thought to contribute to lesion
development. Lymphotoxin-α (LTα) is also a proinflammatory cytokine with homology to
TNFα. However, its presence or function in lesion development has not been investigated.
To study the role of these molecules in atherosclerosis, the expression of these cytokines in
atherosclerotic lesions was examined. The presence of both cytokines was observed within …
necrosis factor-α (TNFα) is an inflammatory cytokine that is thought to contribute to lesion
development. Lymphotoxin-α (LTα) is also a proinflammatory cytokine with homology to
TNFα. However, its presence or function in lesion development has not been investigated.
To study the role of these molecules in atherosclerosis, the expression of these cytokines in
atherosclerotic lesions was examined. The presence of both cytokines was observed within …