[HTML][HTML] Rho Family GTPases Bind to Phosphoinositide Kinases (∗)
KF Tolias, LC Cantley, CL Carpenter - Journal of Biological Chemistry, 1995 - ASBMB
Rho family GTPases appear to play an important role in the regulation of the actin
cytoskeleton, but the mechanism of regulation is unknown. Since phosphoinositide 3-kinase
and phosphatidylinositol 4, 5-bisphosphate have also been implicated in actin
reorganization, we investigated the possibility that Rho family members interact with
phosphoinositide kinases. We found that both GTP-and GDP-bound Rac1 associate with
phosphatidylinositol-4-phosphate 5-kinase in vitro and in vivo. Phosphoinositide 3-kinase …
cytoskeleton, but the mechanism of regulation is unknown. Since phosphoinositide 3-kinase
and phosphatidylinositol 4, 5-bisphosphate have also been implicated in actin
reorganization, we investigated the possibility that Rho family members interact with
phosphoinositide kinases. We found that both GTP-and GDP-bound Rac1 associate with
phosphatidylinositol-4-phosphate 5-kinase in vitro and in vivo. Phosphoinositide 3-kinase …