[HTML][HTML] Disruption of 3-Phosphoinositide-dependent Kinase 1 (PDK1) Signaling by the Anti-tumorigenic and Anti-proliferative AgentN-α-tosyl-l-phenylalanyl …
The anti-tumorigenic and anti-proliferative effects ofN-α-tosyl-l-phenylalanyl chloromethyl
ketone (TPCK) have been known for more than three decades. Yet little is known about the
discrete cellular targets of TPCK controlling these effects. Previous work from our laboratory
showed TPCK, like the immunosuppressant rapamycin, to be a potent inhibitor of the 70-
kilodalton ribosomal S6 kinase 1 (S6K1), which mediates events involved in cell growth and
proliferation. We show here that rapamycin and TPCK display distinct inhibitory mechanisms …
ketone (TPCK) have been known for more than three decades. Yet little is known about the
discrete cellular targets of TPCK controlling these effects. Previous work from our laboratory
showed TPCK, like the immunosuppressant rapamycin, to be a potent inhibitor of the 70-
kilodalton ribosomal S6 kinase 1 (S6K1), which mediates events involved in cell growth and
proliferation. We show here that rapamycin and TPCK display distinct inhibitory mechanisms …