[HTML][HTML] Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic …
Y Song, N Fukuda, C Bai, T Ma, MA Matthay… - The Journal of …, 2000 - ncbi.nlm.nih.gov
Y Song, N Fukuda, C Bai, T Ma, MA Matthay, AS Verkman
The Journal of physiology, 2000•ncbi.nlm.nih.govAquaporin (AQP) water channels provide a major pathway for osmotically driven water
movement across epithelial and microvascular barriers in the lung. We used mice deficient
in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the
hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung fluid
clearance and formation of lung oedema after acute lung injury.
movement across epithelial and microvascular barriers in the lung. We used mice deficient
in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the
hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung fluid
clearance and formation of lung oedema after acute lung injury.
Abstract
1. Aquaporin (AQP) water channels provide a major pathway for osmotically driven water movement across epithelial and microvascular barriers in the lung. We used mice deficient in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung fluid clearance and formation of lung oedema after acute lung injury.
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