Mast cells as sentinels of innate immunity
Mast cells are widely regarded as important effector cells in immune responses associated
with Th2 cells and IgE. Recent work shows that they can also contribute significantly to the
expression of innate immunity; furthermore, survival in a model of acute bacterial infection
that is dependent on complement and mast cells can be greatly enhanced by long-term
treatment of mice with the kit ligand (stem cell factor) at least in part because of the effects of
such treatment on mast cell numbers and/or function. These findings not only indicate that …
with Th2 cells and IgE. Recent work shows that they can also contribute significantly to the
expression of innate immunity; furthermore, survival in a model of acute bacterial infection
that is dependent on complement and mast cells can be greatly enhanced by long-term
treatment of mice with the kit ligand (stem cell factor) at least in part because of the effects of
such treatment on mast cell numbers and/or function. These findings not only indicate that …
Mast cells are widely regarded as important effector cells in immune responses associated with Th2 cells and IgE. Recent work shows that they can also contribute significantly to the expression of innate immunity; furthermore, survival in a model of acute bacterial infection that is dependent on complement and mast cells can be greatly enhanced by long-term treatment of mice with the kit ligand (stem cell factor) at least in part because of the effects of such treatment on mast cell numbers and/or function. These findings not only indicate that mast cells can represent a critical component of host defense in natural immunity but also suggest that mast cell function in this setting can be manipulated for therapeutic ends.
Elsevier