Molecular pathogenesis of B cell malignancy: the role of BCL-6
R Dalla-Favera, A Migliazza, CC Chang, H Niu… - Mechanisms of B Cell …, 1999 - Springer
R Dalla-Favera, A Migliazza, CC Chang, H Niu, L Pasqualucci, M Butler, Q Shen…
Mechanisms of B Cell Neoplasia 1998: Proceedings of the Workshop held at the …, 1999•SpringerHuman malignancies displaying a mature B cell phenotype include non-Hodgkin
lymphoma,(NHL), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM).
Analogous to most cancer types, the pathogenesis of these malignancies represents a
multistep process involving the progressive and clonal accumulation of multiple genetic
lesions affecting proto-oncogenes and tumor suppressor genes. However, several important
features distinguish the mechanism and type of genetic alterations associated with NHL …
lymphoma,(NHL), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM).
Analogous to most cancer types, the pathogenesis of these malignancies represents a
multistep process involving the progressive and clonal accumulation of multiple genetic
lesions affecting proto-oncogenes and tumor suppressor genes. However, several important
features distinguish the mechanism and type of genetic alterations associated with NHL …
Abstract
Human malignancies displaying a mature B cell phenotype include non-Hodgkin lymphoma, (NHL), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM). Analogous to most cancer types, the pathogenesis of these malignancies represents a multistep process involving the progressive and clonal accumulation of multiple genetic lesions affecting proto-oncogenes and tumor suppressor genes. However, several important features distinguish the mechanism and type of genetic alterations associated with NHL, CLL, and MM (Table 1).
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