Up-regulated expression of MICA and proinflammatory cytokines in skin biopsies from patients with seborrhoeic dermatitis
LL Molinero, M Gruber, J Leoni, A Woscoff… - Clinical …, 2003 - Elsevier
Seborrhoeic dermatitis is a disease of unknown etiopathogenesis that affects 5% of the
population. In this study, we investigated expression of mRNA for IL-1α, IL-6, IL-4, IFN-γ, and
the stress-inducible MICA molecule in skin biopsies from 12 patients with moderate to
severe seborrhoeic dermatitis and 2 healthy volunteers by RT-PCR and hybridization with
specific probes. Eight patients expressed INF-γ, 2 expressed IL-6, 8 expressed IL-1α, and 2
expressed IL-4 (1 with moderate disease). Eight patients expressed inflammatory cytokines …
population. In this study, we investigated expression of mRNA for IL-1α, IL-6, IL-4, IFN-γ, and
the stress-inducible MICA molecule in skin biopsies from 12 patients with moderate to
severe seborrhoeic dermatitis and 2 healthy volunteers by RT-PCR and hybridization with
specific probes. Eight patients expressed INF-γ, 2 expressed IL-6, 8 expressed IL-1α, and 2
expressed IL-4 (1 with moderate disease). Eight patients expressed inflammatory cytokines …