[HTML][HTML] TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3′-kinase/protein kinase B signaling pathway
MHH Nguyen, JMY Ho, BK Beattie… - Journal of Biological …, 2001 - ASBMB
A subset of chromosomal translocations that participate in leukemia involve activated
tyrosine kinases. Theets transcription factor, TEL, undergoes translocations with several
distinct tyrosine kinases including JAK2. TEL-JAK2 transforms cell lines to factor
independence, and constitutive tyrosine kinase activity results in the phosphorylation of
several substrates including STAT1, STAT3, and STAT5. In this study we have shown that
TEL-JAK2 can constitutively activate the phosphatidylinositol 3′-kinase (PI 3′-kinase) …
tyrosine kinases. Theets transcription factor, TEL, undergoes translocations with several
distinct tyrosine kinases including JAK2. TEL-JAK2 transforms cell lines to factor
independence, and constitutive tyrosine kinase activity results in the phosphorylation of
several substrates including STAT1, STAT3, and STAT5. In this study we have shown that
TEL-JAK2 can constitutively activate the phosphatidylinositol 3′-kinase (PI 3′-kinase) …