[HTML][HTML] Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells
E Kim, P Ambroziak, JC Otto, B Taylor, M Ashby… - Journal of Biological …, 1999 - ASBMB
Little is known about the enzyme (s) required for the endoproteolytic processing of
mammalian Ras proteins. We identified a mouse gene (designated Rce1) that shares
sequence homology with a yeast gene (RCE1) implicated in the proteolytic processing of
Ras2p. To define the role of Rce1in mammalian Ras processing, we generated and
analyzedRce1-deficient mice. Rce1 deficiency was lethal late in embryonic development
(after embryonic day 15.5). Multiple lines of evidence revealed that Rce1-deficient embryos …
mammalian Ras proteins. We identified a mouse gene (designated Rce1) that shares
sequence homology with a yeast gene (RCE1) implicated in the proteolytic processing of
Ras2p. To define the role of Rce1in mammalian Ras processing, we generated and
analyzedRce1-deficient mice. Rce1 deficiency was lethal late in embryonic development
(after embryonic day 15.5). Multiple lines of evidence revealed that Rce1-deficient embryos …