[PDF][PDF] A line of Berlin Druckrey IV rats proposed as a new model for human hereditary ataxia
CL Guyer, G Stoica, JE Womack, RW Storts, JN Derr… - in vivo, 2002 - researchgate.net
An experimental colony of Berlin Druckrey IV (BD IV) rats with inherited, congenital,
gradually progressive incoordination and rear limb ataxia was evaluated for clinical Signs,
gross and microscopic nervous system lesions, and mode of inheritance of the gene defect.
Clinical evaluation suggested a lesion in the midbrain or brainstem, with resulting lower
motor neuron functional impairment. Gross alterations in affected rats Were atrophy of thigh
musculature by six months of age and thoracic kyphoscoliosis. Histological evaluation of the …
gradually progressive incoordination and rear limb ataxia was evaluated for clinical Signs,
gross and microscopic nervous system lesions, and mode of inheritance of the gene defect.
Clinical evaluation suggested a lesion in the midbrain or brainstem, with resulting lower
motor neuron functional impairment. Gross alterations in affected rats Were atrophy of thigh
musculature by six months of age and thoracic kyphoscoliosis. Histological evaluation of the …