[HTML][HTML] Signaling—2000 and beyond
T Hunter - Cell, 2000 - cell.com
Cell, 2000•cell.com
When the history of signal transduction is written in 2100, what will be remembered of the
exciting advances that occurred in the latter half of the twentieth century? Everyone will
surely have their own list of landmark findings that have contributed to our current picture of
signal transduction. Undoubtedly there are seminal earlier events, but from my own
perspective this era began with the discovery in the mid-1950s that phosphorylation can
reversibly alter the activity of an enzyme through the combined action of a protein kinase …
exciting advances that occurred in the latter half of the twentieth century? Everyone will
surely have their own list of landmark findings that have contributed to our current picture of
signal transduction. Undoubtedly there are seminal earlier events, but from my own
perspective this era began with the discovery in the mid-1950s that phosphorylation can
reversibly alter the activity of an enzyme through the combined action of a protein kinase …
When the history of signal transduction is written in 2100, what will be remembered of the exciting advances that occurred in the latter half of the twentieth century? Everyone will surely have their own list of landmark findings that have contributed to our current picture of signal transduction. Undoubtedly there are seminal earlier events, but from my own perspective this era began with the discovery in the mid-1950s that phosphorylation can reversibly alter the activity of an enzyme through the combined action of a protein kinase and a protein phosphatase (
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