Resiniferatoxin-induced loss of plasma membrane in vanilloid receptor expressing cells
RM Caudle, L Karai, N Mena, BY Cooper, AJ Mannes… - Neurotoxicology, 2003 - Elsevier
Resiniferatoxin (RTX), a potent analog of capsaicin, was evaluated electrophysiologically in
dorsal root ganglion (DRG) cells and cell lines ectopically expressing the vanilloid receptor
type 1 (VR1) to determine if cell phenotype influenced RTXs neurotoxic properties.
Furthermore, capsaicin and heat activation of VR1 were evaluated in these cells to
determine if cellular damage was unique to RTX activation of the receptors. RTX application
to DRG cells identified as type 1, 2 or 5, cell types known to express VR1, induced large …
dorsal root ganglion (DRG) cells and cell lines ectopically expressing the vanilloid receptor
type 1 (VR1) to determine if cell phenotype influenced RTXs neurotoxic properties.
Furthermore, capsaicin and heat activation of VR1 were evaluated in these cells to
determine if cellular damage was unique to RTX activation of the receptors. RTX application
to DRG cells identified as type 1, 2 or 5, cell types known to express VR1, induced large …