[CITATION][C] The role of mitochondrial KATP channels in cardioprotection

GJ Gross - Basic research in cardiology, 2000 - Springer
GJ Gross
Basic research in cardiology, 2000Springer
Ischemic Preconditioning (IPC) is a phenomenon in which single or mutiple short periods of
ischemia or hypoxia (21) result in a marked reduction in infarct size, the extent of stunning
and the incidence of cardiac arrhythmias following a more prolonged period of ischemia.
Although a number of mediators and signaling molecules have been proposed to mediate
this phenomenon, opening of the adenosine triphosphate sensitive potassium channel
(KATP channel) seems to be a common effector molecule involved in IPC. In addition, KATP …
Ischemic Preconditioning (IPC) is a phenomenon in which single or mutiple short periods of ischemia or hypoxia (21) result in a marked reduction in infarct size, the extent of stunning and the incidence of cardiac arrhythmias following a more prolonged period of ischemia. Although a number of mediators and signaling molecules have been proposed to mediate this phenomenon, opening of the adenosine triphosphate sensitive potassium channel (KATP channel) seems to be a common effector molecule involved in IPC. In addition, KATP channel openers have been shown to produce beneficial effects in a number of models of ischemia/reperfusion injury (12). Currently there have been two KATP channels identified in the heart (13), the sarcolemmal channel (sarc KATP) and the more recently discovered mitochondrial channel (mito KATP). There is currently some controversy concerning the relative importance of these two channels in mediating the cardioprotective effect of IPC and following the administration of KATP openers (13). Therefore, it is the purpose of this review to discuss the evidence which supports a role for the mito KATP channel in IPC and cardioprotection in the presence of KATP openers.
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