Signal transduction of ischemic preconditioning

R Schulz, MV Cohen, M Behrends… - Cardiovascular …, 2001 - academic.oup.com
R Schulz, MV Cohen, M Behrends, JM Downey, G Heusch
Cardiovascular research, 2001academic.oup.com
1. Ischemic preconditioning and its endpoints morphological protection, while on the other
hand caution should be used when extrapolating findings from short-Brief episodes of
ischemia/reperfusion protect the termrecoveryofcontractilefunctiontoreductio… myocardium
from the damage induced by subsequent more size. prolonged ischemia. When first
described by Murry et al. Ischemic preconditioning protects against arrhythmias in [1] such
ischemic preconditioning was elicited by brief mice [21], rats [22–24], rabbits [25] and dogs …
1. Ischemic preconditioning and its endpoints morphological protection, while on the other hand caution should be used when extrapolating findings from short-Brief episodes of ischemia/reperfusion protect the termrecoveryofcontractilefunctiontoreductionofinfarct myocardium from the damage induced by subsequent more size. prolonged ischemia. When first described by Murry et al. Ischemic preconditioning protects against arrhythmias in [1] such ischemic preconditioning was elicited by brief mice [21], rats [22–24], rabbits [25] and dogs [26]. In pigs, coronary occlusion, and the endpoint was reduced infarct however [27–30], ischemic preconditioning not only fails size. Soon, however, a variety of preconditioning stimuli to reduce the incidence of ventricular fibrillation during were uncovered including hypoxia [2], rapid cardiac ischemia/reperfusion, but even accelerates the onset of pacing [3, 4], thermal stress [5], stretch [6, 7] and various ventricular fibrillation during sustained ischemia and depharmacological agents (for review, see Refs.[8, 9]). Also, creases the ventricular fibrillation threshold [27]. These various endpoints of ischemic preconditioning have been pro-arrhythmic effects cannot be blocked by glibenused: ischemic preconditioning protects against infarction clamide, indicating that the acceleration of ventricular in all species tested so far (for review, see Ref.[8]), and fibrillation by preconditioning is not a consequence of there is also evidence that it might be operative in man (for K channel activation [29]. Therefore, the present review
Oxford University Press