Hepatocyte growth factor promotes cell survival from Fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death–inducing signaling …
A Suzuki, M Hayashida, H Kawano, K Sugimoto… - Hepatology, 2000 - Elsevier
The Akt/PI-3 kinase pathway is a system essential for cell survival. In the current study, we
showed that hepatocyte growth factor (HGF) activates the Akt/PI-3 kinase pathway to
suppress Fas-mediated cell death in human hepatocellular carcinoma (HCC; 3 lines; SK-
Hep1, HLE, and Chang Liver cell lines), hepatoblastoma (1 line; HepG2), and embryonic
hepatocyte (1 line; WRL). Five tested cell lines showed the resistance to Fas-mediated cell
death by the pretreatment of HGF. This HGF-induced cell survival was suppressed by …
showed that hepatocyte growth factor (HGF) activates the Akt/PI-3 kinase pathway to
suppress Fas-mediated cell death in human hepatocellular carcinoma (HCC; 3 lines; SK-
Hep1, HLE, and Chang Liver cell lines), hepatoblastoma (1 line; HepG2), and embryonic
hepatocyte (1 line; WRL). Five tested cell lines showed the resistance to Fas-mediated cell
death by the pretreatment of HGF. This HGF-induced cell survival was suppressed by …