[HTML][HTML] Tumor necrosis factor-regulated biphasic activation of NF-κB is required for cytokine-induced loss of skeletal muscle gene products
KJ Ladner, MA Caligiuri, DC Guttridge - Journal of Biological Chemistry, 2003 - ASBMB
NF-κB activation is classically defined as a transient response initiated by the degradation of
IκB inhibitor proteins leading to nuclear import of NF-κB and culminating with the resynthesis
of IκBα and subsequent inactivation of the transcription factor. Although this type of
regulation is considered the paradigm for NF-κB activation, other regulatory profiles are
known to exist. By far the most common of these is chronic or persistent activation of NF-κB.
In comparison, regulation of NF-κB in a biphasic manner represents a profile that is scarcely …
IκB inhibitor proteins leading to nuclear import of NF-κB and culminating with the resynthesis
of IκBα and subsequent inactivation of the transcription factor. Although this type of
regulation is considered the paradigm for NF-κB activation, other regulatory profiles are
known to exist. By far the most common of these is chronic or persistent activation of NF-κB.
In comparison, regulation of NF-κB in a biphasic manner represents a profile that is scarcely …