ULBP4 is a novel ligand for human NKG2D
NJ Chalupny, CL Sutherland, WA Lawrence… - Biochemical and …, 2003 - Elsevier
NJ Chalupny, CL Sutherland, WA Lawrence, A Rein-Weston, D Cosman
Biochemical and biophysical research communications, 2003•ElsevierThe ULBPs are a family of MHC class I-related molecules. We have previously shown that
ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human
natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which
contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which
are GPI-linked proteins. Transduction of ULBP4 into EL4 cells confers the ability to bind
recombinant NKG2D and mediates increased cytotoxic activity by human NK cells …
ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human
natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which
contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which
are GPI-linked proteins. Transduction of ULBP4 into EL4 cells confers the ability to bind
recombinant NKG2D and mediates increased cytotoxic activity by human NK cells …
The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which are GPI-linked proteins. Transduction of ULBP4 into EL4 cells confers the ability to bind recombinant NKG2D and mediates increased cytotoxic activity by human NK cells, consistent with the role of ULBPs as ligands for the NKG2D/DAP10 activating receptors. Tissue expression of ULBP4 differs from other members of the family, in that it is expressed predominantly in the skin.
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