[HTML][HTML] Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice
Y Terauchi, J Matsui, R Suzuki, N Kubota… - Journal of Biological …, 2003 - ASBMB
Although we and others have generated IRS-2 knock-out (IRS-2−/−) mice, significant
differences were seen between the two lines ofIRS-2−/− mice in the severity of diabetes and
alterations of β-cell mass. It has been reported that although IRS-1 and IRS-3 knock-out
mice showed normal blood glucose levels, IRS-1/IRS-3 double knock-out mice exhibited
marked hyperglycemia. Thus, IRS-1 and IRS-3 compensate each other's functions in
maintaining glucose homeostasis. To assess the effect of genetic background and also …
differences were seen between the two lines ofIRS-2−/− mice in the severity of diabetes and
alterations of β-cell mass. It has been reported that although IRS-1 and IRS-3 knock-out
mice showed normal blood glucose levels, IRS-1/IRS-3 double knock-out mice exhibited
marked hyperglycemia. Thus, IRS-1 and IRS-3 compensate each other's functions in
maintaining glucose homeostasis. To assess the effect of genetic background and also …