Waterfall sequence for intrinsic blood clotting
EW Davie, OD Ratnoff - Science, 1964 - science.org
EW Davie, OD Ratnoff
Science, 1964•science.orgA simple waterfall sequence is proposed to explain the function of the various protein
clotting factors during the formation of the fibrin clot. When clotting is initiated, each clotting
factor except fibrinogen is converted to a form that has enzymatic activity. This activation
occurs in a stepwise sequence with each newly formed enzyme reacting with its specific
substrate, converting it to an active enzyme.
clotting factors during the formation of the fibrin clot. When clotting is initiated, each clotting
factor except fibrinogen is converted to a form that has enzymatic activity. This activation
occurs in a stepwise sequence with each newly formed enzyme reacting with its specific
substrate, converting it to an active enzyme.
A simple waterfall sequence is proposed to explain the function of the various protein clotting factors during the formation of the fibrin clot. When clotting is initiated, each clotting factor except fibrinogen is converted to a form that has enzymatic activity. This activation occurs in a stepwise sequence with each newly formed enzyme reacting with its specific substrate, converting it to an active enzyme.
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