RNA interference: on the road to an alternate therapeutic strategy!
RS Dave, RJ Pomerantz - Reviews in medical virology, 2003 - Wiley Online Library
RS Dave, RJ Pomerantz
Reviews in medical virology, 2003•Wiley Online LibraryRNA interference (RNAi) is a newly described natural biological phenomenon mediated by
small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular
enzymes. RNAi has become a method of choice for studying gene function, especially in
mammalian systems. With proof‐of‐concept studies already presented against a wide
variety of human pathogens and several innovative methods of delivering the siRNA to a
wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy …
small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular
enzymes. RNAi has become a method of choice for studying gene function, especially in
mammalian systems. With proof‐of‐concept studies already presented against a wide
variety of human pathogens and several innovative methods of delivering the siRNA to a
wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy …
Abstract
RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof‐of‐concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright © 2003 John Wiley & Sons, Ltd.
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