[HTML][HTML] Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation

G Pearson, R Bumeister, DO Henry, MH Cobb… - Journal of Biological …, 2000 - ASBMB
The Raf family of serine/threonine protein kinases is intimately involved in the transmission
of cell regulatory signals controlling proliferation and differentiation. The best characterized
Raf substrates are MEK1 and MEK2. The activation of MEK1/2 by Raf is required to mediate
many of the cellular responses to Raf activation, suggesting that MEK1/2 are the dominant
Raf effector proteins. However, accumulating evidence suggests that there are additional
Raf substrates and that subsets of Raf-induced regulatory events are mediated …