[PDF][PDF] MMP9 potentiates pulmonary metastasis formation
LCL Van Kempen, LM Coussens - Cancer cell, 2002 - cell.com
Cancer cell, 2002•cell.com
Tumor cell dissemination to distant organ sites is a complex process involving multiple cell
types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this
issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a
key role in prepping premetastatic sites for eventual malignant cell growth in a manner
dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).
types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this
issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a
key role in prepping premetastatic sites for eventual malignant cell growth in a manner
dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).
Abstract
Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).
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