[HTML][HTML] Identification of metabolites of importance in the pathogenesis of pulmonary cryptococcoma using nuclear magnetic resonance spectroscopy
U Himmelreich, C Allen, S Dowd, R Malik… - Microbes and …, 2003 - Elsevier
Primary lung infection with Cryptococcus neoformans is characterised by circumscribed
lesions (cryptococcomas). To identify cryptococcal and/or host products of importance in
pathogenesis, we applied proton nuclear magnetic resonance (NMR) spectroscopy, which
identifies mobile compounds present in complex mixtures, to experimental pulmonary
cryptococcomas from rats. Magnetic resonance experiments were performed on
cryptococcomas (n= 10) and healthy lungs (n= 8). Signal assignment to key metabolites was …
lesions (cryptococcomas). To identify cryptococcal and/or host products of importance in
pathogenesis, we applied proton nuclear magnetic resonance (NMR) spectroscopy, which
identifies mobile compounds present in complex mixtures, to experimental pulmonary
cryptococcomas from rats. Magnetic resonance experiments were performed on
cryptococcomas (n= 10) and healthy lungs (n= 8). Signal assignment to key metabolites was …