Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes
S Aytug, D Reich, LE Sapiro, D Bernstein, N Begum - Hepatology, 2003 - Elsevier
Patients with hepatitis C virus (HCV) infection have a greater risk of developing type 2
diabetes mellitus. However, the mechanism of this association is unclear. In this study, we
examined the potential defects in upstream insulin signaling pathways in liver specimens
obtained from nonobese/nondiabetic subjects with HCV infection. Fasting liver biopsy
specimens were obtained from 42 HCV-infected subjects and 10 non-HCV-infected subjects
matched for age and body mass index. Liver tissues were exposed to insulin and examined …
diabetes mellitus. However, the mechanism of this association is unclear. In this study, we
examined the potential defects in upstream insulin signaling pathways in liver specimens
obtained from nonobese/nondiabetic subjects with HCV infection. Fasting liver biopsy
specimens were obtained from 42 HCV-infected subjects and 10 non-HCV-infected subjects
matched for age and body mass index. Liver tissues were exposed to insulin and examined …