[HTML][HTML] Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues
E Tiravanti, A Samouilov, JL Zweier - Journal of Biological Chemistry, 2004 - ASBMB
In addition to the generation from specific nitric-oxide (NO) synthases, NO formation from
nitrite occurs in ischemic tissues, such as the heart. Although NO binding to heme-centers is
the basis for NO-mediated signaling as occurs through guanylate cyclase, it is not known if
this process is triggered with physiologically relevant periods of sublethal ischemia and if
nitrite serves as a critical substrate. Therefore electron paramagnetic resonance studies
were performed to measure nitrosylheme formation during the time course of myocardial …
nitrite occurs in ischemic tissues, such as the heart. Although NO binding to heme-centers is
the basis for NO-mediated signaling as occurs through guanylate cyclase, it is not known if
this process is triggered with physiologically relevant periods of sublethal ischemia and if
nitrite serves as a critical substrate. Therefore electron paramagnetic resonance studies
were performed to measure nitrosylheme formation during the time course of myocardial …