[HTML][HTML] Cystic Fibrosis Transmembrane Regulator-independent Release of ATP: ITS IMPLICATIONS FOR THE REGULATION OF P2Y2RECEPTORS IN AIRWAY …

WC Watt, ER Lazarowski, RC Boucher - Journal of Biological Chemistry, 1998 - ASBMB
The cystic fibrosis (CF) transmembrane regulator (CFTR) is a cyclic AMP-dependent Cl−
channel that is defective in CF cells. It has been hypothesized that CFTR exhibits an ATP
release function that controls the airway surface ATP concentrations. In airway epithelial
cells, CFTR-independent Ca 2+-activated Cl− conductance is regulated by the P2Y 2
receptor. Thus, ATP may function as an autocrine signaling factor promoting Cl− secretion in
normal but not CF epithelia if ATP release is defective. We have tested for CFTR-dependent …