Purinergic modulation of rat urinary bladder detrusor smooth muscle

JA King, H Huddart, WG Staff - General Pharmacology: The Vascular …, 1997 - Elsevier
Rat detrusor muscle was responsive to both ATP and adenosine; ATP elicited an excitatory
response, whereas adenosine had an inhibitory effect. 2. ATP and adenosine had an
inhibitory modulatory action on responses to acetylcholine, potassium depolarization and
field stimulation. 3. Quinidine inhibited the ATP response and blocked the inhibitory effect of
ATP on acetylcholine, potassium-depolarization and field-stimulation responses. The effect
of adenosine remained unaltered in the presence of quinidine. 4. Caffeine and theophylline …