“The force be with you”: ATP in gut mechanosensory transduction

HJ Cooke, J Wunderlich, FL Christofi - Physiology, 2003 - journals.physiology.org
HJ Cooke, J Wunderlich, FL Christofi
Physiology, 2003journals.physiology.org
Nucleotides such as ATP and UTP are everywhere. They play a key role in transducing
mechanosensory signals via P2Y receptors in the large intestine or colon, leading to
secretion of the sensory mediator 5-HT, and act as autocrine, paracrine, or neurocrine
mediators in neural reflexes regulating chloride secretion.
Nucleotides such as ATP and UTP are everywhere. They play a key role in transducing mechanosensory signals via P2Y receptors in the large intestine or colon, leading to secretion of the sensory mediator 5-HT, and act as autocrine, paracrine, or neurocrine mediators in neural reflexes regulating chloride secretion.
American Physiological Society