[HTML][HTML] Purinergic receptors coupled to intracellular Ca2+ signals and exocytosis in rat prostate neuroendocrine cells
Rat prostate neuroendocrine cells (RPNECs) display a variety of ion channels and exhibit α-
adrenergic regulation of cytosolic Ca 2+ concentration ([Ca 2+]) c. In this study, purinergic
regulation of [Ca 2+] c and exocytosis was investigated in freshly isolated single RPNECs
showing chromogranin A immunoreactivity. The presence of P2X and P2Y receptors in
RPNECs was verified by the transient activation of Ca 2+-permeable cationic channels and
the release of Ca 2+ from intracellular stores by extracellular ATP, respectively. The transient …
adrenergic regulation of cytosolic Ca 2+ concentration ([Ca 2+]) c. In this study, purinergic
regulation of [Ca 2+] c and exocytosis was investigated in freshly isolated single RPNECs
showing chromogranin A immunoreactivity. The presence of P2X and P2Y receptors in
RPNECs was verified by the transient activation of Ca 2+-permeable cationic channels and
the release of Ca 2+ from intracellular stores by extracellular ATP, respectively. The transient …