[HTML][HTML] Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes
Store-operated channels (SOCs) provide an important means for mediating longer-term Ca
2+ signals and replenishment of Ca 2+ stores in a multitude of cell types. However, the
coupling mechanism between endoplasmic reticulum stores to activate plasma membrane
SOCs remains unknown. In DT40 chicken B lymphocytes, the permeant inositol
trisphosphate receptor (InsP 3 R) modifier, 2-aminoethoxydiphenyl borate (2-APB), was a
powerful activator of store-operated Ca 2+ entry between 1–10 μm. 2-APB activated …
2+ signals and replenishment of Ca 2+ stores in a multitude of cell types. However, the
coupling mechanism between endoplasmic reticulum stores to activate plasma membrane
SOCs remains unknown. In DT40 chicken B lymphocytes, the permeant inositol
trisphosphate receptor (InsP 3 R) modifier, 2-aminoethoxydiphenyl borate (2-APB), was a
powerful activator of store-operated Ca 2+ entry between 1–10 μm. 2-APB activated …